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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
A final combination: If you take Cialis with certain other medications, it is important to discuss your options with your healthcare provider, who may need to adjusted the dosage or require an interaction with your other drugs. awarding its members a spot on the American journal “Drug and Food” after its 2018 clinical trials. Cialis and erectile dysfunction were the first and only FDA-approved medications to treat erectile dysfunction (ED) and premature ejaculation (PE), respectively. Cialis and erectile dysfunction are used to manage premature ejaculation, which is when a man ejaculates sooner than he or he may benefit from taking a premature ejaculation medication. PE is the inability to achieve an erection during sexual stimulation or during intercourse because of narrowing of the blood vessels in the penis, which is why PE can affect individuals's ability to have and maintain an erection. This medication is available only with your doctor's prescription.Sildenafil for ED: The Sildenafil 100 mg dose is a prescription medication that is used to treat erectile dysfunction (ED) and premature ejaculation (PE) in men.

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Cialis belongs to a class of drug known as phosphodiesterase-5 inhibitors (PDE5i). It is a type of drug that is used to treat erectile dysfunction and benign prostatic hyperplasia. It is available in four doses: 2.5 mg, 5 mg, 10 mg, and 20 mg. Although the doses of 2.5 mg and 5 mg are approved for daily usage in the treatment of ED, the 10 mg dose is yet the most commonly used dose. A consultation with a doctor is recommended to determine a suitable dosage.

How does Cialis work?

To properly understand how Cialis works towards treating ED, it's necessary to first understand how erections work. When there is an erotic stimulus (physical touch, erotic thoughts, sensual scents, etc.), local tissues emit nitric oxide (NO), which raises the quantity of a molecule called cyclic guanosine monophosphate (cGMP). cGMP relaxes the corpora cavernosa muscles on the sides of the penis, allowing blood to flow into the penis. At the same time, veins releasing blood from the penis become constricted, allowing more blood to become trapped in the penis, leading to an erection. Phosphodiesterase-5 is an enzyme that breaks down cGMP, causing the penis to revert to its flaccid state. PDE5 inhibitors, such as Cialis, inhibit this enzyme, resulting in increased amounts of cGMP and a better ability to get and maintain an erection.

Cialis Directions:

Cialis should be taken 30–60 minutes before sexual activity. Cialis is a long-acting medicine that can remain active in your body for up to 36 hours, which is why it is known as a "weekend pill". When Cialis is taken at least 2 hours before sex, some people have better results. Food does not affect Cialis absorption, so it can be taken with or without food.

Side Effects of Cialis:

Some of the common side effects of Cialis are:

  • Nausea
  • Flushing
  • Muscle pain
  • A stuffy or runny nose
  • An upset stomach
  • Headache

If you experience any of these common side effects and they either persist or become worse, get it examined by a doctor. Moreover, if you experience any unforeseen side effects, you should still talk to a doctor.

In some rare cases, cialis can cause some severe side effects. These include:

  • A sudden decline in hearing ability. This may surface in the form of Tinnitus (ringing in the ears) and/or dizziness
  • A sudden loss of vision in one or both eyes. For example, one may experience non-arteritic anterior ischemic optic neuropathy, which is an eye condition that causes sudden vision loss in one or both eyes (NAION).
  • A sudden decrease or loss of muscle mass and function. For example, an individual may have a body weight of more than 100 kg once or twice a week.
  • A sudden decline in prostate specific antigen (PSA) levels. One may notice a decrease in blood flow to the penis, so that the erection may not be as strong as it should be. If this occurs, it is possible to have a heart attack, or a stroke, or a blood clot in the eye, lung, or abdomen. If you experience any sudden vision loss, blurred vision, fast/slow heart rate, chest pain, fainting, or hearing problems, get in touch with our customer care.

It is also possible to experience some other side effects from Cialis, such as:

  • Headache with aits like flu-like symptoms. Get in the headachejoice just after taking Cialis. If you notice a sudden decrease or loss of vision, seek medical help immediately.
  • An allergic reaction to Cialis or any other medication. Symptoms of a allergic reaction may include:
    • Skin rashes
    • Hives
    • Itching/swelling of any kind
    • Skin rash, itching, swelling, dizziness, itching/swelling.
  • a rare cardiovascular event. If you have a heart condition, or if you are taking nitrates in any form, talk to your doctor before taking Cialis alongside a heart event.