1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
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Cialis belongs to a class of drug known as phosphodiesterase-5 inhibitors (PDE5i). It is a type of drug that is used to treat erectile dysfunction and benign prostatic hyperplasia. It is available in four doses: 2.5 mg, 5 mg, 10 mg, and 20 mg. Although the doses of 2.5 mg and 5 mg are approved for daily usage in the treatment of ED, the 10 mg dose is yet the most commonly used dose. A consultation with a doctor is recommended to determine a suitable dosage.
To properly understand how Cialis works towards treating ED, it's necessary to first understand how erections work. When there is an erotic stimulus (physical touch, erotic thoughts, sensual scents, etc.), local tissues emit nitric oxide (NO), which raises the quantity of a molecule called cyclic guanosine monophosphate (cGMP). cGMP relaxes the corpora cavernosa muscles on the sides of the penis, allowing blood to flow into the penis. At the same time, veins releasing blood from the penis become constricted, allowing more blood to become trapped in the penis, leading to an erection. Phosphodiesterase-5 is an enzyme that breaks down cGMP, causing the penis to revert to its flaccid state. PDE5 inhibitors, such as Cialis, inhibit this enzyme, resulting in increased amounts of cGMP and a better ability to get and maintain an erection.
Cialis should be taken 30–60 minutes before sexual activity. Cialis is a long-acting medicine that can remain active in your body for up to 36 hours, which is why it is known as a "weekend pill". When Cialis is taken at least 2 hours before sex, some people have better results. Food does not affect Cialis absorption, so it can be taken with or without food.
Some of the common side effects of Cialis are:
If you experience any of these common side effects and they either persist or become worse, get it examined by a doctor. Moreover, if you experience any unforeseen side effects, you should still talk to a doctor.
In some rare cases, cialis can cause some severe side effects. These include:
It is also possible to experience some other side effects from Cialis, such as: